• LTX-315-enabled, radiotherapy-boosted immunotherapeutic control of breast cancer by NK cells 

      Yamazaki, Takahiro; Wennerberg, Erik; Hensler, Michal; Buqué, Aitziber; Kraynak, Jeffrey; Fucikova, Jitka; Zhou, Xi Kathy; Rekdal, Øystein; Demaria, Sandra; Galluzzi, Lorenzo (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-10)
      LTX-315 is a nonameric oncolytic peptide in early clinical development for the treatment of solid malignancies. Preclinical and clinical evidence indicates that the anticancer properties of LTX-315 originate not only from its ability to selectively kill cancer cells, but also from its capacity to promote tumortargeting immune responses. Here, we investigated the therapeutic activity and immunological ...